Spiramycin I is a macrolide antibiotic and antiparasitic. It binds to the 50S subunit of the ribosome, blocking the channel for peptide chain synthesis, which leads to inhibitory activity against Gram-positive bacteria. Spiramycin I inhibits B. subtilis, M. luteus, S. aureus, S. epidermidis, and S. pneumoniae with MICs ranging from 0.5-8 μg/mL. It also exhibits cytotoxicity in cancer cells (HeLa, KB, MCF-7, HepG2, and U87) with IC50 values between 30.51 and 34.41 μM.
- Binds to the 50S subunit of the ribosome
- Blocks peptide chain synthesis
- Inhibitory activity against Gram-positive bacteria
- Inhibits various bacteria including B. subtilis, M. luteus, S. aureus, S. epidermidis, and S. pneumoniae
- Exhibits cytotoxicity in cancer cells
- For research use only